Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Bioresponsive Polyplex Shielding

Bioresponsive Polyplex Shielding and Endosomal Escape 3.1 Reversible Polyplex Shielding... [Pg.231]

Fig. 1 Bioresponsive polyplexes. (a) Systemic circulation of shielded polyplexes in blood stream and attachment to cell surface receptor (b) endocytosis into endosomes, deshielding by cleavage of PEG linkers and activation of membrane-destabilizing component by acidic pH or other means (c) endosomal escape into cytosol (d) siRNA transfer to form a cytosolic RNA-induced silencing complex complex (e) cytosolic migration and intranuclear import of pDNA (/) presentation of pDNA in accessible form to the transcription machinery... Fig. 1 Bioresponsive polyplexes. (a) Systemic circulation of shielded polyplexes in blood stream and attachment to cell surface receptor (b) endocytosis into endosomes, deshielding by cleavage of PEG linkers and activation of membrane-destabilizing component by acidic pH or other means (c) endosomal escape into cytosol (d) siRNA transfer to form a cytosolic RNA-induced silencing complex complex (e) cytosolic migration and intranuclear import of pDNA (/) presentation of pDNA in accessible form to the transcription machinery...
The following sections discuss how polymers and polyplexes can be chemically designed to be bioresponsive in three key delivery functions (1) polyplex surface shielding, (2) interaction with lipid bilayers, and (3) polyplex stability. [Pg.10]

See other pages where Bioresponsive Polyplex Shielding is mentioned: [Pg.11]    [Pg.227]    [Pg.11]    [Pg.227]    [Pg.11]    [Pg.147]    [Pg.165]    [Pg.166]    [Pg.167]   


SEARCH



Bioresponses

Bioresponsivity

Polyplex

Polyplexes

Polyplexes shielding

Polyplexes shielding, bioresponsive

Polyplexes shielding, bioresponsive

© 2024 chempedia.info