Polypharmacological inhibitors and combinations thereof

From the analysis of kinase selectivity profiles obtained with a broad range of inhibitor scaffolds, clusters of kinases that could be simultaneously inhibited 

The results obtained with bcr-abl also provide early evidence that targeting pockets outside the traditional ATP-binding clef can provide important and alternative pharmacological agents for kinases in cancer and other therapeutic indications. This topic is briefly reviewed in the next section. 

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