Polymeric platinum compounds

Thus, it is extremely important to determine the most effective methods that allow in vivo low drug concentrations. Some basic protocols have been established on restoration of in vivo complex Pt(IV), disintegration polymeric platinum compounds, and slow... 

Plant cleaning incidents, 330 Platinum compounds, 330 Platinum group metals, 331 Poly(aminium) perchlorates, 331 Polyazacaged metal perchlorates, 332 Polycondensation reaction incidents, 332 Poly(dimercuryimmonium) compounds, 332 Poly(dimethylsilyl)chromate, 333 Polymeric peroxyacids, 333 Polymerisation incidents, 333 Polynitroalkyl compounds, 336 Polynitroaryl compounds, 337 Polynitroazopyridines, 340 Polyperoxides, 341 Polypropylene powder, 342 Precious metal derivatives, 342 Preparative hazards, 342... 

Oxidative homocoupling Glaser-Hay polymerization of compound 1 [5] - ,poly[trans-bis (Z)-4-ethynyl-6-(triisopropylsilyl)-3-[(triisopropyl-silyl)ethynyl]-hex-3-ene-l,5-diynyl bis(triethylphosphane)platinum(ll)] (2)... 

The polymeric bis[arcnetellurolato]platinum compounds were depolymerized by tri-phenylphosphane to mononuclear complexes1. 

Only one pure carbonyl has been isolated so far, namely tetra-carbonylnickel, which can be obtained in many ways with very high yields A polymeric platinum carbonyl having the stoichiometry Pt(CO)2 has been recently reported 28) but not fully characterized. On the contrary, many substituted carbonyl compounds, with ligands having As Sb Bi as donor atoms, are known—especially in combination with nickel. These can be obtained in many ways, as follows. 

There are two main aspects of study for the degradation of the platinum polyamines. First, the rate of degradation is important since this should be indicative of the mobility, location, and half life of the polymer in the body. Monomeric platinum compounds typically have more mobility, are less limited to location, and have shorter half lives (less than 24 hours) than their polymeric counterparts. Second, determining the... 

It has been shown (p. 266) that transition metal alkyl compounds containing Cpd and C6H6 groups, ir-bonded to the metal inactivate the metal center for polymerization. It has also been shown by Nyholm and Aresta (45), in the platinum series, that five- or six-membered rings containing only sigma and ir-carbon-to-metal bonds are very stable compounds. These observations add chemical plausibility to reaction (29). 

Polymeric alkene ozonides are shock-sensitive that of trans -2-butene exploded when exposed to friction in a ground glass joint. The use of GLC to analyse crude ozonisation products is questionable because of the heat-sensitivity of some constituents [4], Ozonides are decomposed, sometimes explosively, by finely divided palladium, platinum or silver, or by iron(II) salts [5]. Individually indexed compounds are ... 

The function of an immuno-electrode [28] containing a model antibody (Concanavalin A) fixed in a polymeric film on a platinum electrode is probably based on other effects than those utilized in ISEs. Immuno-electrodes suitable for direct determination of antibodies were prepared by fixing a conjugate of an ionophore and an immunogen (for example the compound of dibenzo-18-crown-6 with dinitrophenol) in a PVC membrane. This system responded to the antibody against dinitrophenol [52, 53]. 

The polymeric nature may inhibit premature drug deactivation. Thus, cisplatin (structure 19.20), the most widely used anticancer drug, is converted into numerous inactive, but more toxic, platinum-containing compounds before it arrives at the targeted cancer cells. Placement of the active platinum-containing moiety into a polymer (structure 19.21) decreases this tendency to hydrolyze into these unwanted cisplatin compounds because of the greater hydrophobic character of the polymeric drug. 

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