Polymer supported techniques, oligosaccharide synthesis

In addition, a novel fluorous support has been developed recently as an alternative to traditional polymer supports and applied successfully to oligosaccharide synthesis in combination with the trichloroacetimidate method [541]. Each intermediate in the fluorous oligosaccharide synthesis [542,543] could be obtained by simple fluorous-organic solvent extraction, and the reactions could be monitored by TLC, NMR and MS, in contrast to solid-phase reactions. Moreover, the new liquid-phase technique is anticipated to be easily applicable to the large-scale synthesis. 

Further breakthroughs in the area of synthetic chemistry emerged with the development of organic synthesis on solid phase.223-226 As a consequence, the past decade has witnessed dramatic improvements in the area of solid phase-supported oligosaccharide synthesis.202,227-230 Polymer-supported synthesis is a very attractive techniques as it allows for rapid synthesis of oligosaccharide sequences without the... 

A promising technique for the tagged oligosaccharide synthesis that makes use of an ionic-liquid support has recently emerged.259 As with the polymer-supported and fluorous tag-supported syntheses, ionic liquid-supported assembly expedites oligosaccharide synthesis by eliminating the need for chromatographic purification of the intermediates. 

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