Polymer-Supported Reagents Preparation and Use in Parallel Organic Synthesis

Polymer-Supported Reagents Preparation and Use in Parallel Organic Synthesis 

The use of polymer-supported reagents (PSRs) [1-4] can combine the benefits of solid-phase chemistry [5-8] with the advantages of solution-phase synthesis, e. g. the simplification of reaction work-up and product isolation. These processes are reduced to simple filtrations (Fig. 1). In addition, PSRs can be used in excess without detriment to the purification step. By using this technique, reactions can be driven to completion more easily than in conventional solution-phase chemistry [9]. 

Some disadvantages of PSRs also need to be mentioned, however. Supporting the active moiety might reduce its activity due to unfavorable electronic and steric 

Combinatorial Chemistiy. Willi Bannwarth, Berthold Hinzen (Eds.) Copyright 2006 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 3-527-30693-5 

Macroporous resins. In contrast to gel-type resins, these are prepared by polymerization in an unreactive solvent, which defines the pore structure. The functionality is largely restricted to the pore surface and is accessible even to solvents and liquid reaction media that are not good sweUing solvents. 

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