Polymer microneedles

Park, J.-H., Allen, M.G. and Prausnitz, M.R. (2005) Biodegradable polymer microneedles fabrication, mechanics and transdermal drug delivery. Journal of Controlled Release, 104, 51-66. 

Park, J. Allen, M. G. Prausnitz, M. R. Polymer microneedles for controlled-release drug delivery. 

Newer developments in ionization methods have tended to overshadow FI, particularly in view of the fragile nature of the emitters and the need for a separate apparatus in which to form the microneedles. In contrast, FD still offers advantages, being able to ionize a wide range of mass spectrometrically difficult substances (peptides, sugars, polymers, inorganic and organic salts,... 

Besides AFM based SMFS, there are several other nanotechnologies which have also been used to measure the minute force in molecular scale, including magnetic beads [6], optical tweezers [7], glass microneedles [8], and biomembrane force probe [9]. These different methods can offer force signals with different timescale and sensitivity. The AFM based SMFS becomes popularized in single polymer chain experiment, because it is relatively easy to be handled. Till now, many elegant experiments have been... 

NayakA, Das DB, Vladisavljevic GT (2014]. Microneedle-asslsted permeation of lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel. Pharm Res, 31,1170-1184. 

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