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Polymer-enzyme liposome therapy

Fig. 15 A Polymer-enzyme liposome therapy (PELT) relies on the liberation of drug from liposomes by the action of a polymer-phospholipase conjugate. B PEGylated liposomal doxorubicin (Doxil) activated by HPMA copolymer-Gly-Gly-phospholipase C conjugate. C Comparison of enzymatic activity of free phospholipase C and HPMA copolymer Gly-Gly-phospholipase C in vitro. Release of doxorubicin from Daunoxomes in the presence of phospholipase C ( ), HPMA copolymer-Gly-Gly-phospholipase C (A) or Triton X-100 (1%) ( ) and in the absence of enzyme as a control ( ) (R. Satchi and R. Duncan, unpublished results)... Fig. 15 A Polymer-enzyme liposome therapy (PELT) relies on the liberation of drug from liposomes by the action of a polymer-phospholipase conjugate. B PEGylated liposomal doxorubicin (Doxil) activated by HPMA copolymer-Gly-Gly-phospholipase C conjugate. C Comparison of enzymatic activity of free phospholipase C and HPMA copolymer Gly-Gly-phospholipase C in vitro. Release of doxorubicin from Daunoxomes in the presence of phospholipase C ( ), HPMA copolymer-Gly-Gly-phospholipase C (A) or Triton X-100 (1%) ( ) and in the absence of enzyme as a control ( ) (R. Satchi and R. Duncan, unpublished results)...
Similarly, HPMA copolymer-phosphohpase C (PEC) conjugates can accelerate drug release from liposomes (Fig. 15B) this polymer-enzyme hpo-some therapy (PELT) [13] could present another opportimity for combi-... [Pg.52]

See other pages where Polymer-enzyme liposome therapy is mentioned: [Pg.10]    [Pg.13]    [Pg.52]    [Pg.4]    [Pg.52]    [Pg.10]    [Pg.13]    [Pg.52]    [Pg.4]    [Pg.52]    [Pg.115]    [Pg.334]    [Pg.420]    [Pg.235]   


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