Polymer brushes phosphorylcholine

Next, in order to demonstrate the efficacy of this cell surface engineering approach, cell microarrays were prepared using a micropattemed poly(2-methacryloyloxyethyl phosphorylcholine [MPC]) (PMPC) polymer brush surface as the substrate. PMPC brushes were prepared on a silicon (Si) wafer via surface-initiated atom transfer radical polymerization, as previously described elsewhere [35]. Selective decomposition of the initiators immobilized on the Si wafer using UV light irradiation resulted in micropatterning of the... 

Hoven et al. [34] used a chemically grafted tris(trimethylsiloxy)silyl (tris(TMS)) monolayer on a silicon oxide substrate as a template for creating nanoclusters of polymer brushes. Surface-initiated polymerization of 2-meth-acryloyloxyethyl phosphorylcholine (MFC) and tert-butyl methacrylate (t-BMA) was used to generate polymer brushes via ATRP from a-bromoester groups tethered to the residual silanol groups on the silicon surface, as... 

In this work, we wiU discuss the characteristic size-exclusion effect and excellent protein repeUency of concentrated brushes on the basis of our experimental data previously reported with poly(2-hydroxyethyl methacrylate) (PHEMA) brushes. PHEMA is a hydrophilic, biocompatible polymer, but the biocompatibility of PHEMA cast film is reported to be not as good as e.g., poly(2-methacryloxyethyl-phosphorylcholine) and poly(2-metho-xyethylacrylate) cast films. Hence any favorable results on the PHEMA brushes could be ascribed more to the structural,... 

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