Polyiodinated triglycerides

Bakan DA, Weichert JP, Longino MA, Counsel RE (2000) Polyiodinated triglyceride lipid emulsions for use as hepatoselective contrast agents in CT effects of physicochemical properties on bio distribution and imaging profiles. Invest Radiol 35 69... 

Longino MA, Bakan DA, Weichert JP, Counsell RE (1996) Eormulation of polyiodinated triglyceride analogues in a chylomicron remnant-like liver selective delivery vehicle. Pharm Res 13 875... 

D.A. Bakan, M.A. Longino, J.P. Weichert and R.E. Counsell, Physicochemical characterization of a synthetic lipid emulsion for hepatocyte-selective delivery of lipophilic compounds application to polyiodinated triglycerides as contrast agents for computed tomography, J. Pharm. Sci. 85 (1996) 908-914. 

Microemulsions of a series of polyiodinated triglycerides (ITG), labeled with iodine-125 and processed in a microfluidizer,were investigated for their contrast enhancement of the liver and the tumor in normal and tumor-bearing (Walker 256) rats, in rabbits bearing VX2 carcinoma, and in normal dogs in CT (911). The mean particle diameter of microemulsions was less than 300 nm. These preparations were stable and autoclavable. Thirty minutes after intravenous injection, from 66 to 78% of the injected dose remained in the liver of the rats. After 3 h the liver still retained from 46% to 93% of the dose. At dose levels ranging from 20 to 70 mg I/kg, the increase in density was reported to be about 40 HU in the rats. In a female pig, the contrast enhancement within 1 h of injection was 90 HU. The liver uptake of ITGs was partially dependent on the formulation vehicle, but the metabolism and clearance from the liver were... 

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