Polyethyleneglycol-Polystyrene Graft Polymers

FIGURE 5.10 Synthesis of a polyethyleneglycol-polystyrene graft polymer by etherification of Merrifield resin using potassium tetra(oxyethylene) oxide, followed by extension of the chain by reaction of the potassium salt, which is present as the crown ether.21 In several TentaGel resins, the connecting bond is an ethyl ether that is more acid-stable than the benzyl ether. 

E Bayer, B Hemmasi, K Albert, W Rapp, M Dengler. Immobilized polyoxyethylene, a new support for peptide synthesis, in VJ Hruby, DH Rich, eds. Peptides 1983. Proceedings of the 8th American Peptide Symposium. Pierce, Rockford, IL, 1983, pp 87-90. 

E Bayer, M Dengler. B Hemmasi. Peptide synthesis on the new polyoxyethylene-polystyrene graft copolymer, synthesis of insulin B21.30. btt J Pept Prot Res 25, 178, 1985. 

E Bayer, W Rapp. Polystyrene-immobilized PEG chains. Dynamics and applications in peptide synthesis, immunology, and chromatography, in JM Harris, ed. Poly(Eth-ylene Glycol) Chemistry Biotechnical and Biomedical Applications. Plenum, New York, 1992, pp 326-345. 

S Zalpsky, JL Chang, F Albericio, G Barany. Preparation and applications of polyethylene glycol-polystyrene graft resin supports for solid-phase peptide synthesis. Reactive Polymers 22, 243, 1994. 

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