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Polyene-sterol interaction has been demonstrated in vitro [Pg.118]

Membranes extracted with organic solvents to remove sterol fail to bind polyenes [Pg.119]

The bulk of nystatin absorbed by Neurospora crassa was found to be located in the microsomal fraction of cell-free homogenates [124,132,160]. Extraction with organic solvents abolished the afflnity of this membrane fraction for the antibiotic. The ability to bind nystatin was restored by pre-incubation of extracted particles with ergosterol. [Pg.119]