Polydimethylsiloxanes toxicology

Joint Assessment of Commodity Chemicals No. 26, Linear Polydimethylsiloxanes (viscosity 10-100,000 centistokes). European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels, 1994 (and references therein). 

Toxicology LD50 (oral) 5000 mg/kg, (skin) 2000 mg/kg eye irritant Hazardous Ingredients Polydimethylsiloxane Hazardous Decomp. Prods. Thermal decomp, may produce formaldehyde... 

Synonyms Polydimethylsiloxane elastomer Polydimethylsiloxane rubber Polysilicone Silicone mbber IMinition Room-temp, vulcanizing silicone mbber Properties Sol. in org. soivs. dens. 1.12 (20C) low surf, tension Toxicology TDFo (implant, rat) 1500 mg/kg skin and eye irritant questionable carcinogen experimental lumorigen Hazardous Decanp. Prods. Heated to decomp., emits acrid smoke and imtating fumes... 

Safety aspects of polysiloxanes (silicones) applications have been an issue since 1948 until now. About 700 publications can be found in the literature, the majority of which are experimental studies on the toxicology of polysiloxanes, including the commonly used group called polydimethylsiloxane (PDMS). However, a review of the Hterature, which consists of both reports and publications, reveals that some issues remain unanswered, namely ... 

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