Polycarbonyl compounds

17 Carbonyl Compounds II. Enols Enolate Anions. Unsaturated and Polycarbonyl Compounds 

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Anticoagulant therapy was developed with the adventitious discovery of dicoumarol (8). A fuller discussion of the rationale for the use of such compounds is found in the chapter on Five-Mem-bered Heterocycles Fused to One Benzene Ring. The reader s attention is directed, however, at the fact that dicoumarol is a polycarbonyl compound containing a very acidic hydrogen. A series of similarly acidic 1,3-indandiones have been found to constitute an additional class of anticoagulant agents. 

The condensation of 4-methoxy-6-methylpyran-2-one with the polyanion derived from pentane-2,4-dione or heptane-2,4,6-trione leads to chromones via the acyclic polycarbonyl compound (76LA1617). 

Carboethoxypropyl)zinc iodide, 220 Hexamethylphosphoric triamide, 142 a-Methylbenzylamine, 185 Titanium(IV) chloride, 304 Miscellaneous compounds including polycarbonyl compounds Diazomethane-Alumina, 14... 

CARBONYL COMPOUNDS II. ENOLS AND ENOLATE ANIONS. UNSATURATED AND POLYCARBONYL COMPOUNDS... 

Experiments, based on the hypothesis that the behaviour of suitably chosen (our italics) aromatic molecules on vigorous pyrolysis should closely or even exactly parallel the fragmentations of the corresponding molecular ions in the mass spectrometer , have led to an improved synthesis of biphenylene (R. F. C. Brown and Solly, 1966). The mass spectra of polycarbonyl compounds (29-31) were used as a guide to the selection of suitable precursors of biphenylene and its derivatives by... 

The addition reactions of amines to polycarbonyl compounds are important ways of making heterocyclic compounds. An example is the condensation of ammonia with hexane-2,5-dione to give 2,5-dimethylpyrrole. 

A wide diversity of o-aryl substituents result in cyclization products on irradiation. Representative examples of this type of reaction from the current literature are given here for illustrative purposes. Japanese workers have studied the irradiation of several m- and -substituted aromatic polycarbonyl compounds and... 

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