Polyanhydrides chemical characterization

The development of new polyanhydrides has sparked researchers to developed new device fabrication and characterization techniques, instrumentation, and experimental and mathematical models that can be extended to the study of other systems. The growing interest in developing new chemistries and drug release systems based on polyanhydrides promises a rich harvest of new applications and drug release technologies, as well as new characterization techniques that can be extended to other materials. Future endeavors will likely focus on multicomponent polyanhydride systems, combining new chemical functionalities to tailor polyanhydrides for specific applications. 

To understand the properties that make polyanhy-drides suitable drug carriers, their chemical, physical, and thermal behavior need to be characterized. This section discusses the methods to determine the chemical structure and composition, the molecular weight, the thermal properties, the phase behavior, the stability, and the erosion mechanism of polyanhydrides. 

McCann, D.L. Heatley, F. D Emanuele, A. Characterization of chemical structure and morphology of eroding polyanhydride copolymers by liquid-state and solid-state IH n.m.r. Polymer 1999, 40 (8), 2151-2162. 

In the past decade, extensive research has been carried out on the characterization of polyanhydrides. This section will describe the methods used for the characterization of polyanhydrides and data obtained about their chemical composition and structure, crystallinity and thermal properties, mechanical properties, and thermodynamic and hydrolytic stability. 

Polyanhydrides have been characterized with regard to their chemical composition, structure, crystallinity and thermal properties, mechanical properties, thermodynamic properties, and hydrols c stability A representative set of analysis data has been summarized for the polyanhydrides poly(EAD-SA) and poly(CPP-SA) (Table 4). H NMR spectroscopy indicates the degree of randomness that suggests whether the polyanhydrides is either a random or a block copolymer the average length of sequence (Ln) and the frequency of occurrence of specific comonomers sequences (58). The anhydride bond presents characteristic peaks in... 

Polyanhydrides have been intensively investigated as important biomaterials in medical fields due to their excellent biodegradability and biocompatibility. Over the decades, numerous studies have been carried out in academia and industry which were mainly concerned with chemical and physical characterization of these polymers, degradation properties, toxicity studies and various... 

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