Polyamines synthesis, solid support

Scheme 15.21. Synthesis of polyamine dendrons on solid support.

A common inhibitor of the latter enzyme is the polyamine alkaloid kukoamine A (10). The synthesis of trypanothione and kukoamine A and their analogs was recently performed on solid support, as described in Sect. 3.2. 

Most of the polyamine syntheses on solid support have been carried out on resins that are modified from Merrifield (100), Wang (101), and Rink-Amide resins (102) (Fig. 19) depending on the synthesis strategies, the coupling procedures, and the branching, fii this review, we illustrate the polystyrene (PS) scaffold of the resins as depicted in Fig. 19. Table 1 presents an overview of the most common resins used in polyamine synthesis (103-120), which will be described in the remaining sections. 

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