Polyacetal-diethylstilboestrol

M. Vicent, R. Tomlinson, S. Brocchini, R. Duncan, Polyacetal-diethylstilboestrol a polymeric drug designed for pH-triggered activation, J. Drug Target. 12 (2004) 491-501. 

Vicent, M. I, Tomlinson, R., Brocchini, S. and Duncan, R. (2004) Polyacetal-diethylstilboestrol A polymeric drug designed for ph-triggered activation. J Drug Target, 12,491-501. 

We also reported the fer-polymerization strategy with the intent to combine DES (diethylstilboestrol), which is a diol, into the polymer backbone [23]. Hydrolytic degradation studies with these bioresponsive polymers showed an enhanced rate of hydrolysis of the polymer backbone at pH 5.5, in which 65% of DES was released over 96h, in comparison to pH 7.4, where only 4% of DES was released during the same time [23]. This DES containing ter-polyacetal has continued to be developed by Vicent etal. [32,71]. 

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