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Poly polymerase cleavage assay

Like other bacterial ADP-ribosylating toxins (e.g. diphtheria toxin. Pseudomonas aeruginosa exotoxin A, cholera toxin, pertussis toxin, and C. botulinum C2 toxin (Aktories and Just, 1993)), C3 is a mono-ADP-ribosyltransferase (Aktories et ai, 1988b). Treatment of ADP-ribosylated Rho with phosphodiesterase releases 5 -AMP and not phosphoribosyl-AIVtP, a cleavage product of poly(ADP-ribose) (Aktories et ai, 1988b Rubin ef a/., 1988). Accordingly, thymidine, an inhibitor of poly(ADP-ribose)polymerase, does not block C3-like ADP-ribosyltransferases, and can be included in C3 ADP-ribosylation assays to block poly-ADP-ribosylation reactions. [Pg.66]

Assay of cleavage of known intracellular caspases substrates (i.e., Poly ADP Ribose Polymerase)... [Pg.4]

See other pages where Poly polymerase cleavage assay is mentioned: [Pg.66]    [Pg.228]    [Pg.83]    [Pg.90]    [Pg.47]    [Pg.170]    [Pg.174]    [Pg.24]    [Pg.199]    [Pg.80]    [Pg.92]    [Pg.184]    [Pg.65]   


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Poly polymerase

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