Poly films platelet adhesion

In previous papers(i-.3), we have reported that a specially prepared poly(vinyl alcohol) (PVA) film is very low in protein adsorption and platelet adhesion compared with conventional PVA and other polymers. When PVA is used for practical applications as non aqueous solutions, physical or chemical crosslinking or acetalization is introduced to PVA to make it insoluble in water. Acetalization with formaldehyde and physical crosslinking by heat treatment (annealing) are the most common among the insolubilization methods(. However, for the minimum protein adsorption and platelet adhesion, these physical and chemical modifications have to be avoided because significant interactions with biological components are observed for such PVA, similar to the conventional polymers. 

Polyethylene glycol (PEG) is another well-known molecule used to reduce protein adsorption and/or platelet adhesion. Surface enrichment of a triblock oligomeric PEG containing additive from a polyurethane matrix was reported [54,55]. The authors used PEG as the active groups to suppress protein and platelet adhesion. The authors first synthesized a methylene diphenyl diisocyanate (MDI)-poly (tetramethylene oxide) (PTMO) 1000 prepolymer with a MW of approximately 4750 (PU4750), and then this prepolymer was terminally functionalized with mono amino-polyethylene oxide (PEG) with different MW (PEO550, 2000, or 5000, Table 2.3). This triblock copolymer was mixed with a polyurethane (MDI/ PTMO 1000/ethylene diamine (ED)) at different ratios in dimethylformamide (DMF) and cast into polymer films. The surface compositions of these films were evaluated by XPS. 

Zhang F, Kang ET, Neoh KG, Wang P, Tan KL. Reactive coupling of poly(ethylene glycol) on electroactive polyanUine films for reduction in protein adsorption and platelet adhesion. Biomaterials 2002 23 787-95. 

Nagahama K, Ohya Y, Ouchi T. Suppression of cell and platelet adhesion to star-shaped 8-armed poly(ethylene glycol)-poly(L-lactide) block copolymer films. Macromol Biosci 2006 6 412--119. 

Poly(methyl methacrylate) Polymer films Reduction in plasma protein adsorption, and platelet adhesion Control of thrombus formation in cardiovascular applications... 

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