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Poly drug loading effect

Microspheres (10 to 200 pm in diameter) of poly(fumaric acid—cose-bacic acid) anhydride (20 80) [P(FA SA)] were shown to exhibit very strong and pronounced mucoadhesive properties both in vitro and in vivo.143 145 The microspheres were tested for their effect on GI transit of low-molecular-weight drugs salicylic acid and dicumarol. As compared with the control (drug-loaded alginate microspheres of similar size), the P(FA SA) microspheres significantly delayed the GI transit of these drugs in rats.145... [Pg.194]

Figure 1. Effect of NaOH on thioridazine release from poly(DL-lactide) microspheres. Key (0) no NaOH, 15-85 pm (A) 0.045 mole NaOH/mole lactic acid, 10-75 pm ( ) 0.14 mole NaOH/mole lactic acid, 10-75 pm. Drug loading, 43%. Emulsifier, sodium oleate. Figure 1. Effect of NaOH on thioridazine release from poly(DL-lactide) microspheres. Key (0) no NaOH, 15-85 pm (A) 0.045 mole NaOH/mole lactic acid, 10-75 pm ( ) 0.14 mole NaOH/mole lactic acid, 10-75 pm. Drug loading, 43%. Emulsifier, sodium oleate.
Effect of Drug Loading on the Rate of Nicotine Release from Poly(e-caprolactone) Matrices... [Pg.80]

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See also in sourсe #XX -- [ Pg.61 , Pg.62 ]



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