Polar Mapping and Conformational Analysis of Macrocycles

The actual notation is illustrated for the diamond form of cyclodecane (see Fig. 1.4) and 179. The dihedral angles were measured from a Dreiding ModeF (this can also be done with appropriate computer 

When substituents are attached to large rings, they tend to occupy only exterior positions to minimize the large transannular interactions. A fully substituted atom of a macrocycle will usually occupy a corner position since this is the only position where it does not cause severe transannular strain. For both substituted and unsubstituted macrocycles, the conformation of the ring will impose restraints on the torsional angles available to each unit of carbons (four carbons define a torsional angle). If these four atoms are shown 

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