Polar functional group drugs with

As demonstrated, SIS rubber and silicone copolymers are relatively inert drugs thus little interaction happens with these adhesives. But the acrylic copolymer easily causes interactions with drugs when polar functional groups exist in the copolymer. The extent of the interaction of drugs with the copolymer significantly influences the diffusion of drugs in the PSA matrix, and even affects drug stability. 

The set of all computed A values is a descriptor with the ability to identify typical patterns of properties in a molecule, e.g., the. distance of two polar functional groups or the distance of lipophilic groups. Due to the importance of functional groups as interaction sites of drag molecules, the autocorrelation coefficients are very helpful in classifying or describing drugs. 

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