Points to Consider in Human Somatic

FDA. (1996). Points to Consider in Human Somatic Cell Therapy and Gene Therapy. 

FDA (1996) Addendum to the points to consider in human somatic cell and gene cell therapy, Human Gene Therapy 1 1181-1190. 

FDA Report (1991). Points to consider in human somatic cell therapy and gene therapy. Hum. Gene Ther. 2, 251 256. 

Smith et al. (8) believe that patterns of amino acid sequences in L chains of human myeloma proteins are difficult to reconcile with somatic mutation of a small number of germ line genes. Consider myeloma proteins from different individuals with L chains of the V, subgroup. The genealogy of amino acid sequences indicate that all are derived from some common ancestral gene. The existing sequences indicate the presence of mutations (from an ancestral gene) which are common to some sequences but not to others. To illustrate this point ... 

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