Podocarpus macrophyllus

Podocarpus macrophyllus (Thunb.) D. Don Luo Han Song (Southern yew) (stem bark, leaf, root, fruit) Pinene, camphene, cadinene, podocarpene, neocryuptomerin, kaurene, ecdysterone, ponasterone, makisterones, hinokiflavone, sciadopitysin, podocarpus flavones, macrephyllic acid, podototarin, totarol.54 For ringworms, blood disorders, tonic for heart, kidneys, lungs, stomach. 

Alpinia officinarum, Menyanthes trifoliata, Piper cubeba, Podocarpus macrophyllus, Solidago canadensis, Valeriana altemifolia, V. amurensis, V. fauriei, V. subbipinnatifolia, Zanthoxylum bungeanum Ajuga bracteosa, Azolla imbricata, C. albescens, C. brevicaule, C. littorale, C. maakii, C. segetum,... 

Ecdysterone Achyranthes bidentata, A. japonica, Ajuga bracteosa, A. decumbens, A. pygmaea, Cyathula prostrate, Matteuccia struthiopteris. Osmunda japonica, Podocarpus macrophyllus, Trillium camschatcense... 

Atractylodes chinensis, A. japonica, A. koreana, A. lancea, A. lyrata, A. ovata, A. macmcephala Cycas revoluta, Podocarpus macrophyllus, Selaginella tamarisina, Thuja koraiensis, T. orientalis,... 

Dysosma pleiantha, Podophylium peltatum, P. pleianthum Podocarpus macrophyllus... 

Wih respect to the insecticide activity, Podocarpus macrophyllus is widely known in Japan for its resistance to termite attack. Saeki disclosed in 1970 that the termiticidal activity is entirely due to inumakilactone A (28) and another unidentified compound of similar structure, the former being more active [70]. This second compound was later reported to be nagilactone D (4). 

Structure of the further norditerpenoids of Podocarpus macrophyllus. Inumakilactone A glucoside, a plant growth inhibitor and inumakilactone E. Hayashi, T. Kakisawa, H. Ito, S. Chen, Y.P. Hsu, H-Y. Tetrahedron Lett. 1972,33,3385-3388. 

Termiticidal substances from the wood of Podocarpus macrophyllus. Saeki, I. Sumimoto, M. Kondo, T. Holzforschung 1970,24, 83-86. 

The novel chloroenone quassinoid eurycolactone B (444) was characterized from the roots of Eurycoma longifolia from Malaysia (629). This is the first halogenated quassinoid discovered in a plant. A series of norditerpene dilactones, including the chlorinated rakanmakilactones E (445), G (446), and 447, were isolated from the leaves of Podocarpus macrophyllus from Japan (630, 631). These represent the first halogenated norditerpene dilactones found in the Podocarpaceae. 

Park H-S, Yoda N, Fukaya H, Aoyagi Y, Takeya K (2004) Rakanmakilactones A-F, New Cytotoxic Sulfur-Containing Norterpene Dilactones from Leaves of Podocarpus macrophyllus var. maki. Tetrahedron 60 171... 

Hinokiflavone (biflavone) Rhus succedanea (Anacardiaceae), Araucaria bidwillii (Araucariaceae), Cycas revoluta (Cycadaceae), Cupressusfunebris,Juniperus macropoda (Cupressaceae), Podocarpus macrophyllus (Podocarpaceae), Selaginella tamariscina (water fern) (Selaginellaceae) cAMP PDF (HIV-1 RT)... 

Ponolactone A and its glucoside are inhibitors of expansion and mitosis in plant cells. Ponolactone A was isolated from Podocarpus nakai and shown to have the structure (25) by a detailed study of its n.m.r. spectrum, utilizing the nuclear Overhauser effect. The C-14 epimer was prepared from the C-7 acetate of nagilactone. Inumakilactone B was isolated" from Podocarpus macrophyllus and shown by a combination of chemical and spectroscopic evidence to have the structure (26). Inumakilactone C was tentatively assigned structure (27) on the basis of spectroscopic evidence. 

Cheng, K. T. Hsu, F. L. Chen, S. H. Hsieh, P. K. Huang, H. S. Lee, C. K. Lee, M. H., New constituent from Podocarpus macrophyllus var. macrophyllus shows anti-tyrosinase effect and regrrlates tyrosinase-related proteins and mRNA in human epidermal melanocytes, Chem. Pharm. Bull, 2007, 55, 757-761. 

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