Podocarpus gracilior

Podolide, a new antileukemic norditerpene dilactone from Podocarpus gracilior. Kupchan, S.M. Baxter, S. L. Ziegler, M.F. Smith, P.M. Bryan, R.F. Experientia 1975,31,137-138. 

Multichemical resistanse of the conifer Podocarpus gracilior (Podocarpaceae) to insect attack. Kubo, 1. Matsumoto, T. Klocke, J.A. J. Chem. Ecol, 1984, 10, 547-559. 

Chexal K, Handa B K, Rahman W, Kawano N 1970 Some optically active biflavones from Podocarpus gracilior. Chem Ind (London) 28... 

Kubo I, Klocke J A, Matsumoto T 1983 Identification of two insect growth inhibiting biflavonoids in Podocarpus gracilior. Rev Latinoamer Quim 14 59-61... 

Using tandem mass spectrometry as a probe for the isolation of analogs further studies were carried out on Podocarpus wallichianus, P. gracilior and P. purdieanus. P. wallichianus yielded the novel compound 12 (ref. 61). Compounds 11 and 12 both show activity in 3PS (151% at 20 and 10 mg/kg respectively) and are undergoing further evaluation at NCI. 

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