PntAB gene

Kabus A, GeorgiT, WendischVF, Bott M. Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation. Appl... 

Therefore, it is not surprising that several studies have reported successful 3-HP production by employing this pathway [27, 30-32, 35]. Overexpression of acetyl-CoA carboxylase encoded by the accABCD genes, and C. aurantiacus malonyl-CoA reductase encoded by the mcr gene in E. coli led to the production of 1.6 mM 3-HP. Malonyl-CoA reductase catalyzes the two-step conversion of malonyl-CoA to malonic-semialdehyde and further to 3-HP. It was expected that additional expression of E. coli pntAB genes, to meet the NADPH requirement... 

The production of xylitol from xylose requires only a single step, xylose reductase (XR). The XR gene xyrA from Candida tropicalis was expressed in E. coli and 13.3 gl of xyhtol was produced from xylose [116]. A strain that co-consumes xylose and glucose was used to generate a 56 g 1" xylitol [117]. Another study used a transhydrogenase (PntAB) to achieve theoretical yield of xylitol from glucose in the presence of excess xylose [118]. 

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