Plotosus canius

Plotosus Canius is one of the most deadly venomous Indian Catfish. Its sting produced several pathophysiological alteration and there is no specific treatment due to inadequate information on the venom toxic component. The present investigation isolated a lethal toxic principle and try to explore the underlying mechanism of lethality. 

Auddy B, Alam M I, Gomes A (1993) Pharmacological actions of the venom of the Indian Catfish (Plotosus canius, Hamilton). Ind. J Med Res 99 47-51. ... 

Isolation and purification of Toxin-PC - Protein precipitated with 50% ammonium sulphate saturation possessed lethality (MED 46 pg/20 gm mice, iv. bolus). The fold of purification achieved by the process was 1.95 (Table 1). The same precipitate of the venom was loaded on DEAE cellulose column. Seven distinct protein peaks were eluted. Peak 7 eluted with 0.2 M acetate buffer pH 5.0 and possessed lethality. The fold of purification was found to be 15 with a yield of 8.8% (Table 1), and it was provisionally designated as Toxin-PC (P = Plotosus, C = Canius). 

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