Pleurotus mutilus

The mevalonate labelling pattern of the antibiotic pleuromutilin (5.130), which is produced by the Basidiomycete Pleurotus mutilus (Clitopilus scyphoides), suggests that it is formed (Scheme 5.12) by a more deep-seated rearrangement of a copalyl diphosphate (5.131 5.132 5.133). A derivative, tiamulin , is used in animal health and retapamulin (altabax ) has attracted interest because of its activity against resistant organisms where it selectively targets the bacterial ribosome. 

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