Pleuromutilin Structure

Figure 4 Exemplar structures of various antibiotic classes that bind to either the 505 or the 305 subunit. Macrolides azithromycin (1), oxazolidinones linezolid (2), aminoglycosides Kanamycin A (3), Pleuromutilin (4), phenylpropanoids chloramphenicol (5), lincosamides clindamycin (6), Sparsomycin (7), Anisomycin (8), and tetracycline (9). See Scheme 9 for thiosptrepton (38). Not pictured streptogramins such as quinupristin/dalfopristin.

Schlunzen, E, Pyetan, E., Fucini, P., Yonath, A., Harms, J.M. Inhibition of peptide bond formation by pleuromutilins The structure of the 50s ribosomal subunit from Deinococcus mdiodurans in complex with tiamulin. Mol. Microbiol. 2004, 54(5), 1287. 

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