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Pleuromutilin Hydroxylation

Pleuromutilin (Scheme 17.9) is an antibiotic from Pleurotus or Clitopilus basidiomycete strains which kills mainly Gram-positive bacteria and mycoplasms. Metabolism of pleuromutilin and derivatives results in hydroxylation by microsomal cytochrome P-450 at the 2- or 8-position and inactivates the antibiotics. Modification of the 8-position of pleuromutilin and analogs was of interest as a means of preventing the metabolic hydroxylation. Microbial hydroxylation at the... [Pg.286]

FIGURE 16.20 Anti-infective drugs. Microbial hydroxylation of pleuromutilin 81 or mutilin 82. [Pg.239]

See other pages where Pleuromutilin Hydroxylation is mentioned: [Pg.286]    [Pg.286]    [Pg.286]    [Pg.286]    [Pg.216]    [Pg.237]    [Pg.238]    [Pg.238]   
See also in sourсe #XX -- [ Pg.286 ]



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