Platinum methanol synthesis over

Later it was described the synthesis of the donepezil HCI from 5,6-dimethoxy-2-(pyridin-4-yl)methylene-indan-l-one by the reaction with H2 over platinum dioxide at room temperature in acetic acid-methanol mixture to give 4-[(5,6-dimethoxy-l-indanon)-2-yl]methylpiperidine. The last one yielded donepesyl HCI by refluxing with benzyl bromide and triethylamine for 4 hours with the following addition of methanolic HCI (10%). 

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