Platelets, activation/aggregation aspirin affecting

It was established that PG synthetase is inhibited by aspirin and other acidic NSAIDs. It was determined somewhat later that actual inhibition occurs at the active site of the cyclooxygenase component probably by competing with the polyunsaturated acid substrates such as AA. As will be seen, the PG-mediated effects of inflammation, pain, platelet aggregation, and vasoconstriction are all affected by this enzyme inhibition. 

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