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Platelet reactivity, effect

I 5 Gurbel PA, Bliden KR Samara W, et al. Clopidogrel effect on platelet reactivity in patients with stent thrombosis results of the CREST Study. J Am Coll Cardiol 2005 46 1827-1832. [Pg.150]

Valles J, Santos MT, Aznar J, et al. Erythrocyte promotion of platelet reactivity decreases the effectiveness of aspirin as an antithrombotic therapeutic modality the effect of low-dose aspirin is less than optimal in patients with vascular disease due to prothrombotic effects of erythrocytes on platelet reactivity. Circulation 1998 97 35CA355. [Pg.152]

Gurbel PA, Bliden KR Hiatt BL, O Connor CM. Clopidogrel for coronary stenting response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation 2003 107 2908-2913. [Pg.153]

Other effects Reduced platelet reactivity Increased t-PA and decreased plasminogen activator inhibitor-1 Increased circulating endothelial progenitor cells... [Pg.163]

When each of the acrylate or methacrylate polymers was preincubated with whole plasma, the platelet reactivity of the surfaces upon subsequent exposure to whole blood decreased significantly (Fig. 3). On the other hand, with many other polymers this effect of plasma was not seen. Of 20 varieties of segmented polyurethanes examined, none showed this behavior (22), and platelet adhesion to polystyrene was also unaffected by plasma pretreatment ( ). The phenomenon of plasma-induced passivation of methacrylate and acrylate polymers presumably involves selective adsorption of specific plasma proteins by the surfaces and/or a particular alteration of the adsorbed protein once bound. [Pg.512]

Park KW, Kang J, Park JJ, Yang H-M, Lee H-Y, Kang H-J, et al. Amlodipine, clopidogrel and CYP3A5 genetic variability effects on platelet reactivity and clinical outcomes after percutaneous coronary intervention. Heart September 2012 98(18) 1366-72. [Pg.538]

Interactions of Blood with Multiphase Polymers Effect of Sulfonate-Ester-Contalnlng Domains on Platelet Reactivity... [Pg.1]

Fig. 1. Schematic diagram showing the different mechanisms of action proposed for the antiulcer action of flavonoids. 1. Blockade of add secretion by decreasing histamine production or inhibiting the proton pump. 2. Bactericidal effect on H. pylori. 3. Antioxidative activity by scavenging free radicals and preventing ROM formation. 4. Potentiation of the mucosal protective factors. PAF platelet activating factor ROM reactive oxygen metabolites H2 histamine receptor 2 M muscarinic receptor G gastrin receptor. Fig. 1. Schematic diagram showing the different mechanisms of action proposed for the antiulcer action of flavonoids. 1. Blockade of add secretion by decreasing histamine production or inhibiting the proton pump. 2. Bactericidal effect on H. pylori. 3. Antioxidative activity by scavenging free radicals and preventing ROM formation. 4. Potentiation of the mucosal protective factors. PAF platelet activating factor ROM reactive oxygen metabolites H2 histamine receptor 2 M muscarinic receptor G gastrin receptor.
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Reactivity effects

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