Platelet-activating factor renal effects

The numerous biochemical substances that may be considered with regard to hepatic encephalopathy or ascites have been outlined in detail, (s. tabs. 15.2 16.5) Similarly, an extensive synopsis of pathogenetically effective biochemical factors can be drawn up for HRS as well. All of them ultimately interfere — directly or indirectly - with the renal retention or excretion of sodium and/ or the balance between vasodilation and vasoconstriction. RAAS is markedly activated. (5, 28, 33, 41, 62, 64, 65) (s. tab. 17.1) Vasodilative factors under discussion include bilirubin, bile acids, nitrogen monoxide (NO), false neurotransmitters, calcitonin peptide (25) as well as platelet-activating factor (RAF). In more recent studies, considerably higher plasma values of the vasoconstrictor leukotrienes (C4 and D4) (41) and endothehn 1 and 3 (42) were detected. 

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