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Platelet-activating factor, neurotoxicity

Since predators of snakes (and humans) have to deal with snake venoms as defenses, they are included here, even though they serve in predation. Snake venoms are primarily enzymes (proteins), especially of the phospholipase A2 type, which breaks down cell membrane phospholipids hydrolytically. Other snake venoms such as cobrotoxin contain peptides with 60-70 amino acid residues. Pharmacologically, they have neurotoxic, cytotoxic, anticoagulant, and other effects. The neurotoxins, in turn, can have pre- or postsynaptic effects. Snake venoms with both neurotoxic and hemolytic effects on the heart are known as cardiotoxins. Cytotoxins attach to the cells of blood vessels and cause hemorrhage. Snake venom factors may stimulate or inhibit blood clotting. Finally, platelet-active factors can contribute to hemorrhage. [Pg.257]

Xu Y. and Tao Y. X. (2004). Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. NeuroReport 15 263-266. [Pg.104]

Nogami K, Hirashima Y, Endo S, Takaku A (1997) Involvement of platelet-activating factor (PAF) in glutamate neurotoxicity in rat neuronal cultures. Brain Res 754(l-2) 72-78... [Pg.4729]


See other pages where Platelet-activating factor, neurotoxicity is mentioned: [Pg.188]    [Pg.92]    [Pg.93]    [Pg.300]    [Pg.612]    [Pg.642]    [Pg.300]    [Pg.612]    [Pg.642]    [Pg.56]    [Pg.185]    [Pg.82]    [Pg.120]   
See also in sourсe #XX -- [ Pg.612 ]

See also in sourсe #XX -- [ Pg.612 ]




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Platelet activation factor

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