Platelet-activating factor degradation

FIGURE 25.24 Platelet activating factor, formed from Talkyl-2-lysophosphatidylcholine by acetylation at C-2, is degraded by the action of acetylhydrolase. 

Recent work has focused on the identification of possible biomarkers of sulfur mustard exposure and injury (Buxton et al., 2000, 2001 Danne et al., 2000). More recently, the role of metalloproteinases and collagen degradation (Gerecke et al., 2005), platelet activating factor (Clark et al., 2005, 2006), and interaction with cytochrome P450... 

FIGURE 25-3 Synthesis and degradation of platelet-activating factor. RCOO" is a mixture of fatty acids but is enriched in arachidonic acid that may be metabolized to eicosanoids. CoA, coenzyme A. 

Inhibits platelet aggregation by increasing levels of cAMP Binds protein C, which is then cleaved by thrombin to yield activated protein C this in combination with protein S degrades factors Va and Villa, limiting their actions Activates plasminogen to plas-min, which digests fibrin the action of t-PA is opposed by plasminogen activator inhibitor- (PAI-1)... 

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