Plastics drug affinity

Various chemicals, such as the fibrate (e.g., clofibrate, bezafibrate, and ciprofibrate) and other lipid-lowering drugs (e.g., Wy-14643) and phthalate plasticizers (e.g., diethylhexyl phthalate), bind to and activate PPARa and are also hepa to carcinogenic in rodents. However, different compounds bind with different affinities, from strong (e.g., Wy-14643) to weak (e.g., phthalates). Thus, it is believed that peroxisomal proliferators act via the receptor (PPARa) to cause some of the effects seen. 

Compared to other drugs of abuse, analysis of cannabinoids presents some difficult challenges. THC and 11-OH-THC are highly lipophilic and present in low concentrations in body fluids. Complex specimen matrices, i.e., blood, sweat, and hair, may require multi-step extractions to separate cannabinoids from endogenous lipids and proteins. Care must be taken to avoid low recoveries of cannabinoids due to their high affinity to glass and plastic containers, and to collection devices for alternate matrices (Blanc et al. 1993 Bloom 1982 Christophersen 1986 Joern 1992). THC and THCCOOH are predominantly found in the plasma fraction of blood, where 95% to 99% are bound to lipoproteins. Only about 10% of either... 

M. Paborji. C, M. Riley, and V. J. Stella. A novel use of Intralipid for the parenteral delivery of perilla ketone (NSC 348407), an investigational cytotoxic drug with a high affinity for plastic. Im. J. Phaim., 42 243-249. 1988. 

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