Blood versus plasma clearance

Plasma versus Blood Clearance Calculation of Eh from drug clearance in blood requires the determination of chug concentration in whole blood. Since the determination of chug concentration is usually performed in plasma or serum, knowledge of the blood/plasma concentration ratio is necessary to estimate the blood clearance. Blood clearance is calculated using the equation... 

Toxicokinetics is a term used for describing kinetic studies conducted in conjunction with toxicology evaluations (Di Carlo 1982) that deal with absorption, distribution, and elimination processes of chemicals present at concentrations that produce toxic effects. By monitoring the blood concentrations of the chemical and/or metabolites over time after administration by different routes, the test chemical s bioavailability and kinetic characteristics can be readily obtained. The data also permit the determination of the so-called linear dose range based on area under the plasma versus time curve and clearance or other related toxicokinetic parameters, as well as the prediction of possible bioaccumulation after multiple doses. Changes in kinetic parameters after multiple exposures... 

In most patients with gout, the flow of plasma in the kidney, the glomerular filtration rate, and the renal clearance are normal, and no excess urates are found. Some investigators have claimed that gout is associated with abnormal tubular reabsorption of uric acid (93% in patients with gout versus 91% in normal individuals), leading to an absolute increase in total uric acid reabsorption and an accumulation of uric acid in the blood. 

---