Plasma monkey, disappearance

Prasad et al. [126] developed and used a sensitive and specific spectropho tome trie method for the estimation of primaquine to study the plasma kinetics of primaquine in Rhesus monkeys. It was observed that the drug completely disappeared from the plasma in 24 h after a single oral dose. Its concentration in the plasma reached a peak at 2 h of administration. The mean absorption and elimination half-lives were 0.36 0.08 and 3.44 0.37 h, respectively. 

Figure 2. Plasma disappearance of radiocarbon from monkeys. Oryzalin (2.0 mg/kg) given in ethanol intravenously. N=4.

---