Plackett-Burman screening test

TABLE IV. Application of the Plackett-Burman screening test... 

Optimization of medium composition with response surface methodology Based on the previous Plackett-Burman screening test and the path of steepest ascent experiment design, response surface methodology was applied to determine the optimal conditions of these three significant factors, including initial inulin content, peptone, and liquid medium volume. 

The ruggedness of a method can be tested using two types of experimental designs. Procedure related factors at the one hand are examined mainly in screening designs of the Plackett-Burman or... 

Sorption Screening Tests. The results of the Plackett-Burman sorption screening tests are summarized in Table VI. Comparison of the results for the three sediments show nearly identical rankings of components that are significant in each element s sorption. This similarity in rankings indicated that sorption mechanisms for the three sediments also were similar. 

Plackett and Burman have shown the construction of all matrices for n up to 100, with one exception, (92 x 92) matrix, which they failed to construct. This matrix has been reported later.[2] The Plackett-Burman paper[l] discusses the use of Hadamard matrices to define screening experiments, in which (n —1) variables can be tested in n runs. 

Plackett and Burman published their classical paper in 1946, which has been much cited by chemists. Their work originated from the need for war-time testing of components in equipment manufacture. A large number of factors influenced the quality of these components and efficient procedures were required for screening. They proposed a number of two level factorial designs, where the number of experiments is a multiple of four. Hence designs exist for 4, 8, 12, 16, 20, 24, etc., experiments. The number of experiments exceeds the number of factors, k, by one. 

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