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A surprising feature of the recently discovered compound pironetin is that its binding to a-tubulin inhibits the binding of vinblastine to /i-tubulin... [Pg.270]

Identification of Molecular Target According to the structure-activity relationship analyses, it was speculated that pironetin binds to tubulin covalently by Michael addition via its a,P-unsaturated 8-lactone [6], The biotinylated pironetin... [Pg.259]

See other pages where Pironetin, tubulin binding is mentioned: [Pg.265] [Pg.259] [Pg.270] [Pg.271] [Pg.62] [Pg.63] [Pg.259] [Pg.289]