Pirkle supercritical fluid chromatography

Packed-column SFC also is suitable for preparative-scale enatioseparations. Compared with preparative LC, sub- or supercritical fluid chromatography results in easier product and solvent recovery, reduced solvent waste and cost, and higher output per unit time. Because of its reduced sample capacity, SFC usually allows the separation of 10-100 mg samples per run. Chromatographers can compensate for these sample amounts by using shorter analysis times and repetitive injections (Wolf and Pirkle, 1997). [Pg.192]

Terfloth, G.J., Pirkle, W.H., Lynam, K.G., and Nicolas, E.C. 1995. Broadly applicable polysi-loxane-based chiral stationary phase for high-performance liquid chromatography and supercritical fluid chromatography. Journal of Chromatography A, 705 185-94. [Pg.302]

Wolf, C., Pirkle,W.H. Enantiomer separation by supercritical fluid chromatography on packed columns, Liq. Chroma-togr.-Gas Chromatogr, 1997,15, 352, 354-361, 363. [Pg.249]

Wolf C, Pirkle WH. Enantiomer separation by sub- and supercritical fluid chromatography on rationally designed chiral stationary phases. In Anton K, Berger C, eds. Supercritical Fluid Chromatography with Packed Columns. Chromatographic Science Series. Vol 75. New York Marcel Dekker, 1998, Chap 9. [Pg.538]