Probenecid Piretanide

Simultaneous acetazolamide, amiloride, bendroflumethiazide, benzthiazide, bumetanide, buthiazide, caffeine, canrenone, chlorthalidone, clopamide, lyclothiazide, diclofenamide, ethacrynic acid, hydrochlorothieizide, mesocarb, morazone, piretanide, polythiazide, probenecid, spironolactone, torsemide, triamterene, xipamide... 

Dixey JJ, Noormohamed FH, Pawa JS, Lant AF, Brewerton DA. The influence of nonsteroidal anti-inflammatory drugs and probenecid on the renal response to and kinetics of piretanide inman, Clin Pharmacol Ther( 9SS) 44, 531-9. 

Probenecid decreases the renal clearance of furosemide, but it appears not to alter its overall diuretic effect. Probenecid reduces the natriuretic effects of piretanide, but the clinical relevance of this is not known. Probenecid does not appear to significantly affect bumetanide diuresis. 

A comparative study" into the pharmacological mechanisms underlying the way drugs interfere with the actions of loop diuretics found that probenecid 1 g reduced the peak fractional excretion of sodium produced by a 6-mg dose of oral piretanide by 65%. Another study confirmed that probenecid reduces the natriuretic effects of piretanide. The clinical importance of these changes was not studied. 

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