Piper novae-hollandiae

Vandopsis longicaulis Certain tumour-inhibitory plants of the Piperaceae and Rhizophoraceae families have yielded amides, e.g. A -dibydropiperine (9) occurs in Piper novae-hollandiae Miq. Macrocyclic alkaloids, e.g. azimine (10), have been fully defined. Further evidence for the nature of Lythrum bases has been obtained by synthesis of the overall skeleton. The key step in the synthesis involved formation of the 17-membered ring (11) (12). Directions for the isolation and degradation of piperine (9, with y,5-double bond) have been included in a unique laboratory text. ... 

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