Pinane-2,3-diol

A full paper describing the synthesis and stereochemistry of the four pinane-2,3-diols, summarizing all the earlier work, has appeared. A reagent for the asymmetric reduction of ketones has been prepared from lithium aluminium hydride and two of these diols, (289a) and (289b). ... 

On the other hand, (+)-pinane-2,3-diol (418ab) was also biotransformed easily to give (+) pinane 2,3,5-triol (419ab) and (-)-2,5-dihydroxy-3-pinanone (415a) as the major products and () 2 hydroxy-S-pinanone (414a) as the minor product (Noma et al., 2003) (Figure 19.172). G. cingulata transformed... 

Mosquitocidal and Knockdown Activity Knockdown and mortality activity toward mosquito, Culex quinquefasciatus, was carried out for the metabolites of (+)- (418ab) and (-)-pinane-2,3-diols (418ab ) and (+) and ( ) 2-hydroxy-3-pinanones (414 and 414 ) by Dr. Radhika Samarasekera, Industrial Technology Institute, Sri Lanka. ( ) 2 Hydroxy-3-pinanone (414 ) showed the mosquito knockdown activity and the mosquitocidal activity at the concentration of 1% and 2% (Table 19.16). 

Kamino, F. and M. Miyazawa, 2005. Biotransformation of (-r)-and (-)-pinane-2,3-diol using plant pathogenic fungus, Glomerella cingulata as a biocatalyst. Proceedings of the 49th TEAC, pp. 395-396. 

Noma, Y. and M. Iwami, 1994. Separation and identi cation of terpene convertible actinomycetes S. bottro-pensis SY-2-1, S. ikutamanensis Ya-2-1 and S. humidus Tu-1. Bull. Tokushima Bunri Univ., 47 99-110. Noma, Y., F. Kamino, T. Hashimoto, and Y. Asakawa, 2003. Biotransformation of (+)- and (-)-pinane-2,3-diol and related compounds hy Aspergillus niger. Proceedings of the 47th TEAC, pp. 91-93. 

Noma, Y, F. Kamino, T. Hashimoto, andY. Asakawa, 2003. Biotransfoimation of (H-)- and (-)-pinane-2,3-diol and related compounds by Aspergillus niger. Proc. 47th TEAC, pp. 91-93. 

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