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Pimozide cardiotoxicity

Clarithromycin inhibits the metabolism of pimozide, pimozide plasma concentrations increase, and there is an increased risk of cardiotoxicity through prolongation of the QT interval and fatal ventricular dysrhythmias (3). [Pg.330]

The principal cytochrome P450 isoform involved in pimozide oxidation is CYP3A4 catalyzed N-dealkylation (523). CYP1A2 seems to also be involved. Pimozide may also interfere with the metabolism of substrates by CYP2D6. Potentiation of pimozide-induced cardiotoxicity (prolongation of the QT interval) in patients by clarithromycin-induced inhibition by CYP3A4 N-dealkylation has been reported (524). [Pg.640]

Cardiotoxicity Slowing of cardiac conduction time (increased QTc) leading to sudden death (especially thioridazine, pimozide) Alleged myocarditis... [Pg.59]

Committee on Safety of Medicines. Cardiotoxic effects of pimozide. CurrentProblems( 996) 29. [Pg.761]

See other pages where Pimozide cardiotoxicity is mentioned: [Pg.761]   
See also in sourсe #XX -- [ Pg.2 , Pg.76 ]

See also in sourсe #XX -- [ Pg.76 ]



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Pimozid

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