Phytotherapeutic agents

SR014 Debruyne, F., G. Koch, P. Boyle, et al., and the Groupe d etude PERMAL. Comparison of a phytotherapeutic agent (Permixon) with an alpha-blocker (Tamsulosin) in the treatment of benign prostatic hyperplasia a 1 -year randomized international study. Prog Urol 2002 12(3) 384-392. 

Zlotta AR, Teillac P, Raynaud JP, Schulman CC. Evaluation of male sexual function in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) treated with a phytotherapeutic agent (Permixon ), tamsulosin or finasteride. Eur Urol 2005 48 269-76. 

Brazil In 1994, the Ministry of Health created a commission to evaluate the situation of phytotherapeutic agents in Brazil. The commission... 

Braz J. Efficacy, safety, quality control, marketing, and regulatory guidelines for herbal medicines (phytotherapeutic agents) Med Biol Res 2000 Feb 33(2) 179-189. 

Herbal medicinal products are not explicitly mentioned in the Ph. Eur. but herbal raw materials are included. The reason is that any pharmacist should be able to judge the safety of herbal medicines but not the efficacy of the products. According to EC legislation [14], a herbal medicinal product is any medicinal product, exclusively containing as active ingredients one or more herbal substances or one or more herbal preparations, or one or more such herbal substances in combination with one or more such herbal preparatiOTis. Herbal medicinal products are also referred to in the international literature as herbal medicines, herbal remedies, herbal products, phytomedicines, phytotherapeutic agents or phytopharmaceuticals. The use of herbal medicinal products for the treatment and prevention of disease is called phytotherapy [13]. 

Reports of adverse heib-dmg interactions upon intentional or accidental coingestion of high enough doses of MDPs naturally present in dietary supplements, ritual beverages, and traditional phytotherapeutic medicines (Fig. 5.5) are also clinically abundant [143-146]. Safrole and isosafrole present (Fig. 5.5) in oil of Sassafras, once used as a root-beer flavoring agent, but... 

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