Physiology Sorption, Metabolism, and Excretion

the main benefit of using less volatile fluorinated surfactants may be a decrease in sorption but not necessarily a shorter retention time of organic fluorine. It should be kept in mind that fluorinated surfactants are not the only fluorine-containing substances which may be present in air. 

The concentration of organic fluorine in blood, C, increased exponentially with increasing concentration, C, of the fluorinated surfactant in the air inhaled (Fig. 10.4)  

The elimination of fluorocompounds from the body is usually assumed to be a first-order kinetic process. The half-life of a fluorocompound in the blood or body is used to characterize retention [5,35,36]. However, the first-order elimination plot for Zonyl TBS exhibited curvature, suggesting a departure from uncomplicated kinetics (Fig. 10.6). The elimination of fluorinated surfactants from blood can be viewed as a first-order process with a postexposure time, t, dependent rate constant, /T,  

Kissa and Kinney explained the deviation from simple first-order kinetics by adsorptive site-dependent variation of adsorptive bonding, heterogeneity of the telomer-derived fluorinated surfactant, and involvement of other organs. 

Perfluorooctanoic acid adsorbs on protein in blood [26]. It is is reasonable 

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