Physiology of Glucose-6-phosphatase

Physiology of Glucose-6-phosphatase 1. Relation to Blood Glucose 

Glucose production by rat liver slices obtained from normal, diabetic, adrenalectomized diabetic, and adrenalectomized normal rats shows some correlation with the G-6-Pase activity of the tissue (Table IV) (Ashmore etal., 1956b). However, in time sequence studies, it can be demonstrated that the increased glucose production by the tissue in vitro precedes an increase in the phosphatase activity in the adrenalectomized diabetic rat 

Comparison of Glucose Production and Hepatic Glocose-6-phosphatase Activity  

Rate of Ghtcose-6-phosphatase Relative to Other Pathways 

In assessing the role of G-6-Pase in hepatic metabolism it is of importance to know the rate of the phosphatase pathway in relation to the other available pathways of G-6-P metabolism. In liver, four pathways of metabolism arc available for G-6-P (1) to glycogen via phosphoglucomutase, (2) 

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