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Physiologically-based pharmacokinetic protein binding

Liu X, Smith BJ, Chen C, et al. Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding. J Pharmacol Exp Ther 2005 313(3) 1254—1262. [Pg.433]

Guohua A, Morrie ME. 2012. A physiologically based pharmacokinetic model of mitoxantrone in mice and scale-np to humans a semi-mechanistic model on corporating DNA and protein binding. AAPS J 14 352-354. [Pg.78]

Poulin P, Burczynski FJ, Haddad S. 2015b. The role of extracellular binding proteins in the cellular uptake of drugs impact on quantitative in vitro-to-in vivo extrapolations of toxicity and efficacy in physiologically based pharmacokinetic-pharmacodynamic research. J. Pharm. Sci. 104. doi 10.1002/jps.24571. [Pg.80]

See other pages where Physiologically-based pharmacokinetic protein binding is mentioned: [Pg.73]    [Pg.728]    [Pg.221]    [Pg.190]    [Pg.173]    [Pg.33]    [Pg.234]    [Pg.225]    [Pg.17]    [Pg.81]    [Pg.36]    [Pg.481]    [Pg.84]    [Pg.525]    [Pg.91]    [Pg.222]   
See also in sourсe #XX -- [ Pg.307 , Pg.310 ]



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