Physiological endpoints for human biogeochemical studies

To test this hypothesis, different biogeochemical regions of biosphere in the territory of Ukraine were selected  

The application of this approach can eradicate the difference in the morbidity rates of different nosologies and estimate an extent of a deviation of parameters from an average for the given disease over the country as a whole. The results showed that in the selected zones of the country, there are remarkable deviations of morbidity rates from the average values overall the Ukraine. For instance, in the industrial zone a significant increase of the morbidity rate of the respiratory system (R2 = 0.83) 

Diseases Crimean Dry Steppe region South-eastern Steppe region under strong industrial pollution Western Forest Steppe region under agricultural influence 

However, these results are not sufficient to estimate quantitative dependence on a level of the particular pollutants in the environment. The second working hypothesis on the relationship between pollutants loading and morbidity dynamics in the whole area of North Eurasia has been considered. This hypothesis was estimated using a complicated statistical treatment (Box 3). The considered pollutants were fertilizers, heavy metals, pesticides, radionuclides, oil products, and polycyclic aromatic hydrocarbons, PAH. 

Statistical assessment of morbidity in technogenic and agrogenic biogeochemical provinces of North Eurasia (after Evstafyeva et al., 1999) 

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